Miltenyi Biotec GmbH, Germany
(PI: Dr. Dominik Eckardt)
Development of a microfluidic-based heart-on-a-chip model as a device for modelling cellular therapy approaches
The advertised subproject will be carried out by a PhD student (“Early-stage Researcher”) at Miltenyi Biotec GmbH over a period of 36 months. The recruited researcher will work in the cardiovascular research group headed by Dr. Dominik Eckardt, which develops products and processes for pluripotent stem cell-derived cardiovascular cells and organoids.
She/he will develop and characterize a novel in vitro model enabling functional evaluation of cellular therapy products. The main working tasks of the advertised subproject are:
- Development of standardized protocols for the generation of heart microtissue
- Development of a microfluidic-based heart-on-chip model allowing for non-invasive evaluation of cellular function
- Evaluation of methods for transplanting cardiomyocytes to the heart-on-chip model and non-invasive monitoring of transplant integrity and function
Secondments are planned as follows:
- Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany for 3 months
- Leiden University Medical Center, The Netherlands for 3 months
This subproject is fully funded by the Marie Skłodowska-Curie European Training Network „EUROoC“ (H2020-MSCA-ITN-2018). The monthly salary consists of a living allowance, mobility allowance and family allowance (if applicable). Please visit the EC MSCA webpage for more information. The recruited researcher will have the opportunity to work as part of an international, interdisciplinary team of 15 PhD students, based at universities and industrial firms throughout Europe. She/he will gain a unique skill-set comprising microfabrication, biomaterial science and stem cell differentiation, as well as an overview of different organ-on-a-chip technologies and their implementation at industrial level. She/he is expected to finish the project with a PhD thesis and to disseminate the results through patents (if applicable), publications in peer-reviewed journals and presentations at international conferences.
Marie Skłodowska-Curie European Training Networks (ETNs) are joint research and training projects funded by the European Union. Funding is provided for PhD students from both inside and outside Europe to carry out individual project work in a European country other than their own.
The European training network “EUROoC” is made up of 11 core and 10 associate partners from academia, industry and regulatory agencies, coordinated by Fraunhofer IGB. The network will recruit a total of 15 PhD students for project work lasting for 36 months.
Organ-on-a-Chip (OoC) technology is advancing at breath taking pace due to its potential impact in drug development and personalised treatments of disease. New researchers entering this field must be equipped with a multidisciplinary background ranging from biology to microfluidic chip engineering. EUROoC offers the first complete and coherent European training program on OoC by gathering multidisciplinary participants (biologists, physicists, chemists, engineers) in a multi-sectoral network composed of six companies, three regulation entities and twelve academic institutions.
EUROoC will qualify the next generation of interdisciplinary scientists for all aspects of OoC development and utilisation, including understanding of commercialisation pathways and regulatory aspects. EUROoC furthermore comprises a collection of innovative research projects addressing the development of advanced OoC systems with higher physiological significance going beyond current in vitro testing.
Qualifications / experience
- You are an early-stage researcher: a researcher without a PhD, who is in the first four years (full-time equivalent research experience) of her/his research career, measured from the date when she/he obtained the degree, which would formally entitle her/him to embark on a doctorate.
- You have a M.Sc. graduation in the field of biology, biotechnology, biomedical engineering or related fields
- You have basic knowledge of organ-on-chip and non-invasive imaging technologies as well as related data analysis software.
- You have practical experience in generation of pluripotent stem derivatives like organoids and/or microfluidics and/or imaging technologies.
- Your goal-oriented personality and proactive approach enables you to successfully complete projects
- You are passionate about cardiovascular research.
- Fluency in written and spoken English is a must, German is a plus.
The applicant must not have resided or carried out her/his main activity (work, studies etc.) in Germany for more than 12 months in the past three years.
What Miltenyi Biotec has to offer:
- A modern workplace and exciting opportunities in the development of technologies with a secure future
- Cross-border intercultural cooperation and short communication channels
- A collegial corporate culture and flexible working hours enable time management on your own terms
- Personalized employee development program: specialist and personal training courses provided by our own training academy
- Diverse corporate benefits with regard to employee health, sport, and staff events
How to apply
Please send your CV, a half-page summary of master/diploma thesis, a letter of motivation (up to 2 pages) which states your research experience and interests, and names and contact information of at least two academic referees who could write a letter of recommendation by e-mail to the following address, quoting the reference „EUROoC-IGB-ESR4“:EUROoC@igb.fraunhofer.de
For questions, please contact:
Dr. Dominik Eckardt:
Assessment of applications starts 31st January 2019, applications are possible until 17th February 2019.
Interviews are planned for February/ March 2019.