ESR 12 – Secondment in Uppsala

Hi, my name is Mara Lucchetti (ESR 12) and I am researching the “Integration of iPSC-derived epithelial cells and of on-chip TEER measurement in the HuMiX gut model” at the University of Luxembourg.

The human-microbial cross talk (HuMiX) platform has been developed by Paul Wilmes’ laboratory at the University of Luxembourg in order to study the molecular interactions between the host and microbes under biomimetic conditions. Throughout the years, the HuMiX gut-on-a-chip model has undergone several modifications in order to provide a representative model of the gastrointestinal-microbe environment. The most recent version, being HuMiX 3.0, has in contrast to the previous versions an additional nitrogen (N2) channel, which enables to recreate an anoxic (deficient in oxygen) environment for culturing representative bacterial species from the gut.

The secondment at Uppsala University (UU) from 17 February to 13 March has been planned as part of the EUROoC training program in order to integrate a TEER (transepithelial electrical resistance) measurement system in HuMiX 3.0 to monitor gut epithelial barrier function. During my secondment, Gabriel and myself successfully designed and fabricated thin-film Pt electrodes. These sensors will first be tested in a demonstration prototype before being integrated in HuMiX. Unfortunately, my secondment had to be interrupted due to the COVID-19 crisis. Hence, Gabriel and myself will perform some preliminary tests individually. A second stay at Uppsala University will be planned to complete the project.

Given that I have a biomedical background, I am grateful that I had the opportunity to collaborate with Gabriel and his group at UU to get an insight into microfabrication techniques. Finally, I want to thank Gabriel and his colleagues for their warm welcome and for introducing me to the Swedish culture.

EUROoC Month 15 Meeting & Mid-term Check

The EUROoC Month 15 Meeting & Mid-term Check was hosted by the Leiden University Medical Center (LUMC) in the Netherlands and took place on February 11th and 12th 2020. Despite one beneficiary, who was stopped by the big storm but substituted well by his ESR, all beneficiaries and ESRs attended the meeting and contributed to fruitful discussions and presentations. On February 11, our Project Officer from EU side joined the meeting and evaluated the progress of the project.

This was followed by a two and a half day long workshop on stem cells and a seminar on project and time management, organised by our beneficiaries Miltenyi Biotec B.V. & Co. KG and LUMC.

We would like to thank all participants for their valuable contribution and close cooperation.

See you all in Uppsala in July!

EUROoC Month 8 & ESR Kick-off Meeting

The EUROoC Month 8 & ESR Kick-off Meeting was organized by the Graz University of Technology and took place on 1st of July 2019 at the Institute of Analytical Chemistry and Food Chemistry. All beneficiaries, all recruited ESRs and almost all partner organisations were able to attend in person.

The meeting was combined with the first seminar on Team Science and Communication.

Almost all participants attended the EUROoCS 2019 conference, that took place the following two days.

EUROoC 1st Project Newsletter

The first edition of the EUROoC project newsletter has been published!

We are happy to bring to your attention that the first edition of the EUROoC project newsletter is now available for viewing.

On 20th May 2019 the EUROoC Consortium published its first project newsletter. It aims to summarize updates about publications, project progress and announcements of upcoming events.

Within the first edition, we provide a general overview of the project, a short project update, as well as news from the EUROoCs and relevant events.

Stay tuned and subscribe!

Click here to view the newsletter

1st European Organ-on-Chip Conference

The 1st European Organ-on-Chip ConferenceEUROoC 2019 is coming to Graz, Austria on 2-3 July 2019!

The EUROoC 2019 is a scientific meeting focused on the challenges in the process of designing, fabricating, and implementing microphysiological cell culture systems addressing topics such as microfabrication of 3D matrices, integration of miniaturised sensors, microfluidic interfacing, cellular engineering, parallelization and automation.

Online registration will close May 31, 2019.

ORCHID interim roadmap report

The EU-funded project ORCHID presented its first interim roadmap report entitled: ‘Organ-on-Chip in Development: Towards a European roadmap for Organ-on-Chip’ during the International Organ-on-Chip Symposium on November 8-9 2018 in Eindhoven, the Netherlands. On 28th March 2019 this report was handed over to representatives of IMI and ECSEL Joint Undertakings in Brussels.
This report surveys the current landscape in the research, development, applications and market opportunities for Organ-on-Chip devices to establish the pillars of a European OoC ecosystem. Based on a bibliometric study, a market analysis, expert interviews, and panel discussions held at the ORCHID Vision Workshop (Stuttgart, 23 May 2018), this report outlines presently unmet needs, key challenges, barriers and perspectives of the field, and finally proposes recommendations towards the definition of a European roadmap that could render OoC systems (OoCs) realistic models of human (patho)physiology in the near future. For a the report click here.


EUROoC Kick-off Meeting 10.12.2018

On 10th December, the kick-off meeting of the EUROoC project “Interdisciplinary training network for advancing Organ-on-a-chip technology in Europe”, coordinated by Fraunhofer IGB was held in Stuttgart to give the initial starting point for partners to work.