With a participant count of nearly 500 people, EUROoCS 2022 was a great success. The event spanned over two days of intense discussions, four parallel sessions with topics covering (multi)-organ and disease models, organoids-on-chip, read-out assays, standardization and qualification, among many others. A key takeaway of the conference was the recognition and discussion around standardization and validation of OoCs with the intention of the principles of 3Rs (reduction, replacement, and refinement of animal testing). We are especially proud of our ESRs Alessia (oral), Tarek (oral), Stefanie (oral), Lisette (oral), Kenny (poster), Merve (poster), Mara (poster), Joanna (poster), Tanvi (poster), Anders (poster) and Gabriel (poster) who presented their great achievements in the course of the conference.