New Paper Published on “Microphysiological stem cell models of the human heart”

Our project partners from the Natural and Medical Sciences Institute at the University of Tübingen (NMI), the Leiden University Medical Center (LUMC) and Miltenyi Biotech (MTY) have published a paper on the “Microphysiological Stem Cell Models of the Human Heart”.Models of heart disease and drug responses are increasingly based on human pluripotent stem cells (hPSCs) since their ability to capture human heart (dys-)function is often better than animal models. Simple monolayer cultures of hPSC-derived cardiomyocytes, however, have shortcomings. Some of these can be overcome using more complex, multi cell-type models in 3D. Here we review modalities that address this, describe efforts to tailor
readouts and sensors for monitoring tissue- and cell physiology (exogenously and in situ) and discuss perspectives for implementation in industry and academia. Read more here.