ESR 7

Name: Lisette van Os

Host Organisation: Bern University

Project Title: Investigating acute lung injury on chip

Objectives of the Project

This project is carried out at the University of Bern, in the Organs on Chips technologies (OOC) group of Prof. O. T. Guenat. The lab aims to develop next generation in vitro models combining microfluidics and tissue engineering, focusing mainly on lung, microvasculature and liver. With the lung-on-chip developed by this group, different lung diseases can be investigated, such as acute lung injury (ALI). ALI is a devastating condition with no effective treatment options until today. The main aim of the current project is to investigate acute lung injury on the microscale, in a second-generation lung-on-chip device. The main tasks of this project are:

  1. Study of immune cell recruitment and transmigration upon pro-inflammatory stimulation
  2. Integration of a bead-based multiplex immunoassay for cytokine detection and optical sensors to monitor the cell culture conditions
  3. Correlation of in vitro to in vivo clinical data

Secondments

  • Alexander Mosig, Jena University
  • Maria Tenje, Uppsala University
  • Janick Stucki, AlveoliX

Short Biography

Lisette van Os did a bachelor’s in Biology and a master’s in Medical and Pharmaceutical Drug Innovation at the University of Groningen, The Netherlands. Her master thesis focused on the biomechanical interactions between fibroblasts and the extracellular matrix in Idiopathic Pulmonary Fibrosis (IPF). This project was carried out at the University of California Irvine under the supervision of Prof. E. L. Botvinick and Prof. J. K. Burgess. During her studies she received several awards, amongst which the best presentation award at the Dutch Matrix Biology meeting (2017) and the Groningen University Fund GUF-100 prize for the best student of the medical faculty (2017). Now she is investigating acute lung injury on chip at the University of Bern, under the supervision of Prof. O. T. Guenat.

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